TRALULALA is a nationwide Danish research initiative aiming to ensure evidence-based, high-quality and uniform respiratory care and follow-up for children and adolescents born with esophageal atresia (EA).

Through the TRALULALA cohort, we investigate respiratory symptoms, lung function, imaging and quality of life to better understand the long-term respiratory consequences of EA and associated tracheomalacia (TM).

On our way towards this goal, our research has expanded to address broader questions in pediatric respiratory medicine. AIRWAY explores improved imaging of congenital airway abnormalities, TRALULALA-AZI investigates prevention of respiratory infections in young children with congenital or early-acquired lung disease, and PEARL focuses on physical capacity and exercise in children with respiratory disease.

Together, these projects provide new knowledge and tools to improve how we diagnose, monitor and treat children with airway abnormalities and early structural lung disease.

Our research is built on nationwide collaboration, including the tertiary pediatric pulmonology centers at Rigshospitalet, Odense University Hospital and Aarhus University Hospital, bringing together expertise in rare and complex respiratory diseases in children.

📅 January 2026
🗣️ TRALULALA at DSPAP (Danish Society of Paediatric Pulmonologists)

The TRALULALA team attended the annual meeting of the Danish Society of Paediatric Pulmonologists (DSPAP), where scholar Marie Felby was honoured with the poster award for her presentation of MBW in children with esophageal atresia and tracheomalacia. 

In addition, TRALULALA received continued funding from the Danish Children’s Lung Foundation (Børnelungefonden), supporting the next phases of the project.

The conference provided an important platform to share our work and reinforces the strong national support for advancing research in children with esophageal atresia and tracheomalacia.

📅 Oktober 2025
🗣️ TRALULALA presentations at ERS CONFERENCE in Amsterdam 

The TRALULALA team attended this year’s ERS Congress, where we presented early findings from our pilot study. The presentations was very well received, and the conference provided valuable opportunities to strengthen and expand our international collaborations. We look forward to building on this positive momentum together with our global partners. 

📅 July 2025

🧪 NATIONWIDE CROSS-SECTIONAL STUDY LAUNCHED 

We are pleased to announce the launch of a nationwide cross-sectional study investigating lung symptoms, airway function and quality of life in children born with esophageal atresia.

This phase of the project includes clinical assessments, lung function testing, and patient-reported outcomes, and involves collaboration between multiple pediatric centers across Denmark.

📅 May 2025 

🔍 PILOT STUDY ON LUNG FUNCTIONS TESTING COMPLETED  

We have completed the pilot study assessing various lung function tests in children with esophageal atresia and suspected tracheomalacia.

The study explored feasibility, quality and clinical relevance of spirometry, body plethysmography, multiple breath washout, and cardiopulmonary exercise testing (CPET).

Findings from this pilot will inform the design of the upcoming multicenter cross-sectional study.

→ Full study launch planned for autumn 2025